Article
Sterol-independent, sterol response element-dependent, regulation of low density lipoprotein receptor gene expression.
Journal of lipid research - 1 Aug 1998
Makar R S, Lipsky P E, Cuthbert J A
Abstract excerpt
Stimulation with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore ionomycin increased native low density lipoprotein (LDL) receptor gene expression in the human leukemic T cell line Jurkat when cells were cultured in the absence of sterols and also increased nuclear accumulation of...
Topics
- Base Sequence
- CCAAT-Enhancer-Binding Proteins
- Chloramphenicol O-Acetyltransferase
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation
- Humans
- Ionomycin
- Ionophores
- Jurkat Cells
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- RNA, Messenger
- Receptors, LDL
- Sterol Regulatory Element Binding Protein 1
- Sterol Regulatory Element Binding Protein 2
- Sterols