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Article

Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription.

The Journal of biological chemistry - 27 Aug 1999

Sato R, Miyamoto W, Inoue J, Terada T, Imanaka T, Maeda M

Abstract excerpt

We herein report that mRNA expression of microsomal triglyceride transfer protein (MTP) and its protein synthesis decline in response to sterol depletion in HepG2 cells, and we functionally characterized the MTP gene promoter in an effort to investigate the molecular mechanisms by which MTP gene transcription is regulated. Luciferase assays using truncated versions of the reporter gene revealed that the region at...

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Identifiers

PMID: 10455139
DOI: 10.1074/jbc.274.35.24714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription.PMID 10455139Read ↗

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Functional analysis of promoter variants in the microsomal triglyceride transfer protein (MTTP) gene.Semantic proximity Read ↗

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