Article
Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2010
Ishii Norio, Matsumura Takeshi, Kinoshita Hiroyuki, Fukuda Kazuki, Motoshima Hiroyuki, Senokuchi Takafumi, Nakao Saya, Tsutsumi Atsuyuki, Kim-Mitsuyama Shokei, Kawada Teruo, Takeya Motohiro, Miyamura Nobuhiro, Nishikawa Takeshi, Araki Eiichi
Abstract excerpt
OBJECTIVE: Nifedipine, an L-type calcium channel blocker, protects against the progression of atherosclerosis. We investigated the molecular basis of the antiatherosclerotic effect of nifedipine in macrophages and apolipoprotein E-deficient mice. METHODS AND RESULTS: In macrophages, nifedipine in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.