Article
Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein.
The Journal of biological chemistry - 2 Oct 1998
Worgall T S, Sturley S L, Seo T, Osborne T F, Deckelbaum R J
Abstract excerpt
Membrane physiology, plasma lipid levels, and intracellular sterol homeostasis are regulated by both fatty acids and cholesterol. Sterols regulate gene expression of key enzymes of cholesterol and fatty acid metabolism through proteolysis of the sterol regulatory element-binding protein (SREBP),...
Topics
- Animals
- CCAAT-Enhancer-Binding Proteins
- Cell Line
- Cholesterol
- DNA-Binding Proteins
- Fatty Acids, Unsaturated
- Gene Expression Regulation
- Genes, Reporter
- Hydroxymethylglutaryl-CoA Synthase
- Mutation
- Nuclear Proteins