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Article

SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2.

FEBS letters - 12 Jun 2007

Roder Karim, Zhang Lei, Schweizer Michael

Abstract excerpt

Treatment of HepG2 with all-trans retinoic acid (RA) induces expression of fatty acid synthase (FAS) mRNA and protein. Transfections show that the FAS promoter positively responds to retinoid X receptor (RXR) but not to RA receptor (RAR) agonists. Since RXR alone is capable of mediating the RA response of FAS, the existence of a classical RA-responsive element in the FAS promoter may be ruled out. Binding sites...

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Source

Identifiers

PMID: 17531980
DOI: 10.1016/j.febslet.2007.05.022

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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