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Article

Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoprotein-receptor.

The Journal of steroid biochemistry and molecular biology - 1 Aug 2003

Brüning Jens C, Lingohr Philipp, Gillette Jennifer, Hanstein Bettina, Avci Haluk, Krone Wilhelm, Müller-Wieland Dirk, Kotzka Jörg

Abstract excerpt

Both estrogen and selective estrogen receptor modulators (SERMs) such as tamoxifen and raloxifene have been demonstrated to lower plasma low density lipoprotein (LDL)-cholesterol concentrations by stimulation of LDL receptor gene expression. To determine the molecular mechanisms of estradiol- and tamoxifen-induced LDL receptor expression, we performed transient transfection experiments with luciferase reporter...

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Identifiers

PMID: 14568562
DOI: 10.1016/s0960-0760(03)00263-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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