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Article

Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.

Biochimica et biophysica acta - 1 Jul 2006

Bennati Anna Maria, Castelli Marilena, Della Fazia Maria Agnese, Beccari Tommaso, Caruso Donatella, Servillo Giuseppe, Roberti Rita

Abstract excerpt

3Beta-hydroxysterol Delta(14)-reductase operates during the conversion of lanosterol to cholesterol in mammalian cells. Besides the endoplasmic reticulum 3beta-hydroxysterol Delta(14)-reductase (C14SR) encoded by TM7SF2 gene, the lamin B receptor (LBR) of the inner nuclear membrane possesses 3beta-hydroxysterol Delta(14)-reductase activity, based on its ability to complement C14SR-defective yeast strains. LBR was...

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Source

Identifiers

PMID: 16784888
DOI: 10.1016/j.bbalip.2006.05.004

Genes

LBR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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