The use of two different APC resistance assay systems provides optimal sensitivity and specificity for diagnosing genetic APC resistance.

doi:10.1097/00001721-199707000-00002

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Article

The use of two different APC resistance assay systems provides optimal sensitivity and specificity for diagnosing genetic APC resistance.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jul 1997

Solano C, Hogg A L, Saal R J, Scott D C, Cobcroft R G

Abstract excerpt

We compared the performance characteristics of a commercial dilute Russell's viper venom (DRVV)-based APC resistance assay (Gradipore PC Impedance Test) to a routinely utilized commercial APTT based assay (Coatest APC Resistance Assay). The DRVV based assay offers improved sensitivity and specifi...

Topics

Animals
Biological Assay
Drug Resistance
Factor V
Humans
Mutation
Protein C
Sensitivity and Specificity

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