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Article

Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination.

Gene - 17 Aug 1998

Lee G, Saito I

Abstract excerpt

The Cre recombinase mediates precise site-specific recombination between a pair of loxP sequences through an intermediate containing Holiday junction. The recombination junction in the loxP sequence is located within the asymmetric 8-nucleotide spacer region. To examine the role of each nucleotide sequence of the spacer region in the recombination process, we synthesized a complete set of 24 loxP spacer mutants...

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Identifiers

PMID: 9714735
DOI: 10.1016/s0378-1119(98)00325-4

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