Article
Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination.
Gene - 17 Aug 1998
Lee G, Saito I
Abstract excerpt
The Cre recombinase mediates precise site-specific recombination between a pair of loxP sequences through an intermediate containing Holiday junction. The recombination junction in the loxP sequence is located within the asymmetric 8-nucleotide spacer region. To examine the role of each nucleotid...
Topics
- Base Sequence
- Binding Sites
- Cell Line, Transformed
- DNA
- Gene Expression
- Humans
- Integrases
- Molecular Sequence Data
- Mutation
- Point Mutation
- Recombination, Genetic
- Substrate Specificity
- Viral Proteins