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Article

Identification of Cre residues involved in synapsis, isomerization, and catalysis.

The Journal of biological chemistry - 19 Sept 2003

Lee Linda, Sadowski Paul D

Abstract excerpt

The Cre protein of bacteriophage P1 is a tyrosine recombinase and catalyzes recombination via formation of a covalent protein-DNA complex and a Holliday junction intermediate. Several co-crystal structures of Cre bound to its target lox site have provided novel insights into its biochemical activities. We have used these structures to guide the mutagenesis of several Cre residues that contact the lox spacer...

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Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Recombination, Genetic

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Identifiers

PMID: 12851389
DOI: 10.1074/jbc.M305464200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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