Article
A novel mutant loxP containing part of long terminal repeat of HIV-1 in spacer region: presentation of possible target site for antiviral strategy using site-specific recombinase.
Biochemical and biophysical research communications - 30 Dec 1998
Lee Y, Park J
Abstract excerpt
A site-specific recombinase Cre is responsible for the recombination at a 34 bp loxP site. This system has been investigated for the antiviral strategy to excise proviral DNA from retrovirus-infected cells. It was reported that loxP sites could be inserted into long terminal repeat (LTR) of retro...
Topics
- HIV Infections
- HIV Long Terminal Repeat
- HIV-1
- Integrases
- Mutation
- Protein Binding
- Recombination, Genetic
- Sequence Homology, Nucleic Acid
- Viral Proteins