A novel mutant loxP containing part of long terminal repeat of HIV-1 in spacer region: presentation of possible target site for antiviral strategy using site-specific recombinase.

Abstract excerpt

A site-specific recombinase Cre is responsible for the recombination at a 34 bp loxP site. This system has been investigated for the antiviral strategy to excise proviral DNA from retrovirus-infected cells. It was reported that loxP sites could be inserted into long terminal repeat (LTR) of retrovirus to delete proviral DNA. To apply this system to human immunodeficiency virus type 1 (HIV-1) without inserting any...

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