Article
High frequency of hypermethylation of p14, p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Sept 2008
Takeshima Maiko, Saitoh Masato, Kusano Kaoru, Nagayasu Hiroki, Kurashige Yoshihito, Malsantha Muthumala, Arakawa Toshiya, Takuma Taishin, Chiba Itsuo, Kaku Tohru, Shibata Toshiyuki, Abiko Yoshihiro
Abstract excerpt
BACKGROUND: Oral squamous cell carcinoma and the most common oral pre-malignancies appear to be related to the habit of betel-quid chewing in Sri Lanka. Although hypermethylation of the tumour suppressor genes in oral cancer have been well documented, little information has been available concerning hypermethylation in oral pre-cancerous lesions. In the present study, we investigated the hypermethylation of p14,...
Topics
- Alleles
- Areca
- CpG Islands
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Cytosine
- DNA Methylation
- Epithelium
- Genes, p16