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Article

Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect.

The Journal of physiology - 15 Jan 2003

Wang Shimin, Morales Michael J, Qu Yu-Jie, Bett Glenna C L, Strauss Harold C, Rasmusson Randall L

Abstract excerpt

We studied quinidine block of Kv1.4DeltaN, a K(+) channel lacking N-type inactivation, expressed in Xenopus ooctyes. Initially, quinidine intracellularly blocked the open channel so rapidly it overlapped with activation. This rapid open channel block was reduced (non-additively) by interventions that slow C-type inactivation: [K(+)](o) elevation and an extracellular lysine to tyrosine mutation (K532Y). These...

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Identifiers

PMID: 12527726
DOI: 10.1113/jphysiol.2002.029512
PMCID: PMC2342510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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