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Article

Differential ion current activation by human 5-HT(1A) receptors in Xenopus oocytes: evidence for agonist-directed trafficking of receptor signalling.

Neuropharmacology - 1 Dec 2005

Heusler Peter, Pauwels Petrus J, Wurch Thierry, Newman-Tancredi Adrian, Tytgat Jan, Colpaert Francis C, Cussac Didier

Abstract excerpt

The subject of the present study was the functional and pharmacological characterization of human 5-HT(1A) receptor regulation of ion channels in Xenopus oocytes. Activation of the heterologously expressed human 5-HT(1A) receptor induced two distinct currents in Xenopus oocytes, consisting of a smooth inward current (I(smooth)) and an oscillatory calcium-activated chloride current, I(Cl(Ca)). 5-HT(1A) receptor...

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PMID: 15964603
DOI: 10.1016/j.neuropharm.2005.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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