Article
Genomic Ly49A transgenes: basis of variegated Ly49A gene expression and identification of a critical regulatory element.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2004
Tanamachi Dawn M, Moniot Deborah C, Cado Dragana, Liu Scot D, Hsia Jennifer K, Raulet David H
Abstract excerpt
Several gene families are known in which member genes are expressed in variegated patterns in differentiated cell types. Mechanisms responsible for imposition of a variegated pattern of gene expression are unknown. Members of the closely linked Ly49 inhibitory receptor gene family are expressed in a variegated fashion by NK cells. Variegated expression of these genes results in subsets of NK cells that differ in...
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