Article
Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2002
Silver Elizabeth T, Lavender Kerry J, Gong Dong-Er, Hazes Bart, Kane Kevin P
Abstract excerpt
The Ly-49 multigene receptor family regulates mouse NK cell functions. A number of Ly-49 genes exhibit allelic variation, but the functional significance of allelic differences in extracellular domains of Ly-49 receptors regarding ligand specificity is largely unknown. Amino acid differences exist in the extracellular domains of the B6 and BALB/c allele products of the inhibitory Ly-49G receptor. We constructed...
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