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Article

Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells.

Nature - 27 Jul 1995

Held W, Roland J, Raulet D H

Abstract excerpt

An important feature of natural killer (NK) cell activity is the lysis of cells that have extinguished expression of some or all class I major histocompatibility (MHC) molecules. Accordingly, the Ly49A NK-cell antigen receptor has been shown to deliver an inhibitory signal to NK cells on encounter with Dd or Dk class I MHC on target cells. Ly49A belongs to a family of eight or more highly related, tightly linked...

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PMID: 7630404
DOI: 10.1038/376355a0

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Related research

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Research trail→

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Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells.PMID 7630404Read ↗

An allele-specific, stochastic gene expression process controls the expression of multiple Ly49 family genes and generates a diverse, MHC-specific NK cell receptor repertoire.Semantic proximity Read ↗

Ly49 receptors: evolution, genetic diversity, and impact on immunity.Semantic proximity Read ↗

Ly49A allelic variation and MHC class I specificity.Semantic proximity Read ↗

Expression of natural killer receptor alleles at different Ly49 loci occurs independently and is regulated by major histocompatibility complex class I molecules.Semantic proximity Read ↗

Specificity and function of activating Ly-49 receptors.Semantic proximity Read ↗

Expression of the Ly49A gene in murine natural killer cell clones is predominantly but not exclusively mono-allelic.Semantic proximity Read ↗

Class I MHC-binding characteristics of the 129/J Ly49 repertoire.Semantic proximity Read ↗

Evolution of the Ly49 and Nkrp1 recognition systems.Semantic proximity Read ↗

Ly-49 receptors and their functions.Semantic proximity Read ↗

Evidence for high bi-allelic expression of activating Ly49 receptors.Semantic proximity Read ↗

Regulation of natural killer cell function.Semantic proximity Read ↗

A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.Semantic proximity Read ↗

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