Article
CD8 T cells expressing NK associated receptors are increased in melanoma patients and display an effector phenotype.
Cancer immunology, immunotherapy : CII - 1 Dec 2005
Casado Javier G, Soto Rocío, DelaRosa Olga, Peralbo Esther, del Carmen Muñoz-Villanueva Maria, Rioja Luis, Peña José, Solana Rafael, Tarazona Raquel
Abstract excerpt
CD8+ T cells can express NK-associated receptors (NKRs) that may regulate their cytolytic function. We have characterized the expression of several NKRs on peripheral blood CD8+ T cells from melanoma patients and compared them to age-matched healthy donors. The analysis performed includes HLA class I specific receptors (KIRs, LILRB1 and CD94/NKG2) and other NK receptors like CD57, CD56 and CD16. Melanoma patients...
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