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Article

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

1 Sept 2019

Abstract excerpt

Despite the clinical success of cancer immunotherapies, the majority of patients fail to respond or develop resistance through disruption of pathways that promote neo-antigen presentation on MHC I molecules. Here, we conducted a series of unbiased, genome-wide CRISPR/Cas9 screens to identify genes that limit natural killer (NK) cell anti-tumor activity. We identified that genes associated with antigen...

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Identifiers

PMID: 31509742
DOI: 10.1016/j.celrep.2019.08.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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