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Uncoupling CD4+ TIL-Mediated Tumor Killing from JAK-Signaling in Melanoma

1 May 2023

Abstract excerpt

PURPOSE: Impaired MHCI-presentation and insensitivity to immune effector molecules are common features of immune checkpoint blockade (ICB)-resistant tumors and can be, respectively, associated with loss of β2 microglobulin (B2M) or impaired IFNγ signaling. Patients with ICB-resistant tumors can respond to alternative immunotherapies, such as infusion of autologous tumor-infiltrating lymphocytes (TIL). CD4+ T...

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PMID: 37126006
DOI: 10.1158/1078-0432.ccr-22-3853

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