Article
APOE in non-Alzheimer amyloidoses: transmissible spongiform encephalopathies.
Neurology - 1 Aug 1998
Chapman J, Cervenáková L, Petersen R B, Lee H S, Estupinan J, Richardson S, Vnencak-Jones C L, Gajdusek D C, Korczyn A D, Brown P, Goldfarb L G
Abstract excerpt
BACKGROUND: The APOE genotype has been shown to influence the risk of developing sporadic and familial AD. This effect is isoform-dependent, the APOE epsilon4 allele increasing susceptibility and the APOE epsilon2 allele providing protection. Amyloid formation is an important part of the pathogen...
Topics
- Alleles
- Amyloidosis
- Apolipoproteins E
- Creutzfeldt-Jakob Syndrome
- Genotype
- Gerstmann-Straussler-Scheinker Disease
- Humans
- Iatrogenic Disease
- Kuru
- Mutation
- Periodicity
- Prion Diseases
- Risk Factors