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Article

APOE in non-Alzheimer amyloidoses: transmissible spongiform encephalopathies.

Neurology - 1 Aug 1998

Chapman J, Cervenáková L, Petersen R B, Lee H S, Estupinan J, Richardson S, Vnencak-Jones C L, Gajdusek D C, Korczyn A D, Brown P, Goldfarb L G

Abstract excerpt

BACKGROUND: The APOE genotype has been shown to influence the risk of developing sporadic and familial AD. This effect is isoform-dependent, the APOE epsilon4 allele increasing susceptibility and the APOE epsilon2 allele providing protection. Amyloid formation is an important part of the pathogenesis in AD as well as in spongiform encephalopathies; apoE deposition in amyloid plaques has been documented in both...

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Source

Identifiers

PMID: 9710033
DOI: 10.1212/wnl.51.2.548

Genes

APOE
PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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