Article
Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism.
Neurology - 1 Feb 1996
Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala E L, Hartikainen P, Hänninen T, Ryynänen M, Riekkinen P J
Abstract excerpt
Alzheimer's disease (AD) is a heterogeneous entity presenting as sporadic and familial disease. In familial AD, there is evidence for genetic linkage to a yet undefined gene on chromosome 14 in early-onset pedigrees and on chromosome 19 in late-onset pedigrees. In a few early-onset kindreds, there were mutations in the amyloid precursor gene on chromosome 21. There is an increased frequency of apolipoprotein E...
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