Article
The apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease. The French Research Group on Epidemiology of Human Spongiform Encephalopathies.
Lancet (London, England) - 12 Nov 1994
Amouyel P, Vidal O, Launay J M, Laplanche J L
Abstract excerpt
Creutzfeldt-Jakob disease (CJD) is a rapid progressive mental and neurological disorder characterised by dementia and is both infectious and genetic. Pathogenic mutations and a predisposing polymorphism have been described in the prion protein gene and an abnormal prion product accumulates in the...
Topics
- Aged
- Alleles
- Apolipoproteins E
- Creutzfeldt-Jakob Syndrome
- Disease Susceptibility
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Mutation
- Polymorphism, Restriction Fragment Length
- Prions
- Risk Factors
- Survival Rate