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Article

Mutator phenotype resulting from DNA polymerase IV overproduction in Escherichia coli: preferential mutagenesis on the lagging strand.

Journal of bacteriology - 1 Oct 2005

Kuban Wojciech, Banach-Orlowska Magdalena, Bialoskorska Malgorzata, Lipowska Aleksandra, Schaaper Roel M, Jonczyk Piotr, Fijalkowska Iwona J

Abstract excerpt

We investigated the mutator effect resulting from overproduction of Escherichia coli DNA polymerase IV. Using lac mutational targets in the two possible orientations on the chromosome, we observed preferential mutagenesis during lagging strand synthesis. The mutator activity likely results from extension of mismatches produced by polymerase III holoenzyme.

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Source

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Identifiers

PMID: 16166552
DOI: 10.1128/JB.187.19.6862-6866.2005
PMCID: PMC1251572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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