Ras-related TC21 is activated by mutation in a breast cancer cell line, but infrequently in breast carcinomas in vivo.

Abstract excerpt

Activating ras mutations are found in many types of human tumour. Mutations in Harvey (H-), Kirsten (K-) and neuronal (N-) ras are, however, rarely found in breast carcinomas. TC21 is a ras family member that shares close homology to H-, K- and N-ras, and activating mutations have been found in o...

Topics

• Breast Neoplasms
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Membrane Proteins
• Monomeric GTP-Binding Proteins
• Mutation
• Ovarian Neoplasms
• Polymorphism, Single-Stranded Conformational
• Tumor Cells, Cultured
• Uterine Cervical Neoplasms