Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.

Journal of cancer research and clinical oncology - 1 Dec 2001

Rihet S, Vielh P, Camonis J, Goud B, Chevillard S, de Gunzburg J

Abstract excerpt

PURPOSE: The constitutive activation of Ras proteins by point mutation is the most frequently observed oncogene activation in human malignancies. The goal of this study was to investigate whether the constitutive activation of RhoA, Rac1, and Cdc42 proteins by point mutations, which can lead to experimental transformation of cultured cells, actually occurred in a panel of invasive colorectal and breast tumors....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to cdc42 GTP-Binding Protein

Share to Colorectal Neoplasms

Share to Mutation

Share to Protein Kinase Regulation and GTPase Signaling

Share to rac1 GTP-Binding Protein

Share to rhoA GTP-Binding Protein

Source

Identifiers

PMID: 11768613
DOI: 10.1007/s004320100272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.PMID 11768613Read ↗

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b.Semantic proximity Read ↗

Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts.Semantic proximity Read ↗

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters.Semantic proximity Read ↗

Mutations of genes of the ras family in human and experimental tumors.Semantic proximity Read ↗

Allele loss and point mutation in codons 12 and 61 of the c-Ha-ras oncogene in carcinogen-transformed human breast epithelial cells.Semantic proximity Read ↗

Transforming and oncogenic potential of activated c-Ha-ras in three immortalized human breast epithelial cell lines.Semantic proximity Read ↗

Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer.Semantic proximity Read ↗

Recapitulation of ras oncogene mutations in breast cancer.Semantic proximity Read ↗

Absence of Ras mutations in rat DMBA-induced mammary tumors.Semantic proximity Read ↗

Involvement of Ras Activation in Human Breast Cancer Cell Signaling, Invasion, and AnoikisSemantic proximity Read ↗

Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin.Semantic proximity Read ↗

Mutation patterns in non-ras oncogenes and tumour suppressor genes in experimentally induced tumours.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.