Article
Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancers.
Cancer research - 15 Mar 1991
Moley J F, Brother M B, Wells S A, Spengler B A, Biedler J L, Brodeur G M
Abstract excerpt
Little is known about the prevalence and significance of ras gene activation in neural crest tumors such as neuroblastomas, pheochromocytomas, and medullary thyroid cancers (MTCs). Therefore, we analyzed DNA from 10 human neuroblastoma cell lines and 10 primary human pheochromocytomas for activating mutations in N-ras, H-ras, and K-ras. We also studied DNA from 24 primary neuroblastomas and 10 MTCs for N-ras...
Topics
- Adrenal Gland Neoplasms
- Carcinoma, Papillary
- Genes, myc
- Genes, ras
- Humans
- Mutation
- Neuroblastoma
- Pheochromocytoma
- Polymerase Chain Reaction
- Thyroid Neoplasms
- Tumor Cells, Cultured