Article
Ku70: a candidate tumor suppressor gene for murine T cell lymphoma.
Molecular cell - 1 Jul 1998
Li G C, Ouyang H, Li X, Nagasawa H, Little J B, Chen D J, Ling C C, Fuks Z, Cordon-Cardo C
Abstract excerpt
We present evidence that inactivation of the Ku70 gene leads to a propensity for malignant transformation both in vitro and in vivo. In vitro, Ku70-/- mouse fibroblasts displayed an increased rate of sister chromatid exchange and a high frequency of spontaneous neoplastic transformation. In vivo,...
Topics
- Animals
- Antigens, Nuclear
- Cell Differentiation
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Colony-Forming Units Assay
- DNA Helicases
- DNA Repair
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Fibroblasts
- Gamma Rays
- Genes, Tumor Suppressor
- Hirschsprung Disease
- Ku Autoantigen
- Lymphoma, T-Cell
- Mice