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Article

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

25 Jul 2011

Abstract excerpt

A genome-wide screen for genetic alterations in radiation-induced thymic lymphomas generated from p53+/- and p53-/- mice showed frequent loss of heterozygosity (LOH) on chromosome 6. Fine mapping of these LOH regions revealed three non-overlapping regions, one of which was refined to a 0.2 Mb interval that contained only the gene encoding homeobox-interacting protein kinase 2 (Hipk2). More than 30% of...

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PMID: 21785465
DOI: 10.1038/onc.2011.306

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