Article
Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Baross-Francis A, Andrew S E, Penney J E, Jirik F R
Abstract excerpt
DNA mismatch repair (MMR) deficiency is associated with an increased mutational burden and predisposition to certain malignancies. Relatively little is known, however, about gene-specific mutation frequencies within MMR-deficient primary tumors. Thymic lymphomas from Msh2(-/-) mice were thus anal...
Topics
- Animals
- Bacterial Proteins
- Base Sequence
- DNA
- DNA Repair
- DNA-Binding Proteins
- Escherichia coli Proteins
- Lac Repressors
- Lymphoma
- Mice
- Mice, Transgenic
- MutS Homolog 2 Protein
- Mutation
- Nucleic Acid Heteroduplexes
- Proto-Oncogene Proteins
- Repressor Proteins
- Thymus Neoplasms