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Article

Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998

Baross-Francis A, Andrew S E, Penney J E, Jirik F R

Abstract excerpt

DNA mismatch repair (MMR) deficiency is associated with an increased mutational burden and predisposition to certain malignancies. Relatively little is known, however, about gene-specific mutation frequencies within MMR-deficient primary tumors. Thymic lymphomas from Msh2(-/-) mice were thus analyzed by using a lacI-based transgenic shuttle-phage mutation detection system. All tumors exhibited greatly elevated...

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Identifiers

PMID: 9671748
DOI: 10.1073/pnas.95.15.8739
PMCID: PMC21146

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Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability.PMID 9671748Read ↗

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