Article
Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity.
Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002
Wang Rongfang, Wang-Zhu Yiran, Grey Howard
Abstract excerpt
Previous studies on thymocyte differentiation by using reaggregate cultures (RC) of double positive T cell receptor (TCR) transgenic thymocytes and the thymic epithelial cell line ANV indicated that low concentrations of high affinity ligands for the TCR were efficient inducers of thymocyte maturation to CD4 single positive (SP) functional cells. In this study, it is demonstrated that, when high concentrations of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.