Article
Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males.
Journal of internal medicine - 1 Jul 1998
Hautanena A, Lankinen L, Kupari M, Jänne O A, Adlercreutz H, Nikkilä H, White P C
Abstract excerpt
OBJECTIVES: Two diallelic polymorphisms, one in the transcriptional regulatory region (promoter) and the other in the second intron, have been identified in the aldosterone synthase (CYP11B2) gene encoding aldosterone synthase, the enzyme catalysing the last steps of aldosterone biosynthesis. We...
Topics
- Adrenal Cortex
- Adrenocorticotropic Hormone
- Adult
- Aldosterone
- Analysis of Variance
- Cohort Studies
- Cross-Sectional Studies
- Cytochrome P-450 CYP11B2
- Dexamethasone
- Finland
- Genotype
- Glucocorticoids
- Humans
- Hydrocortisone
- Hypertension
- Introns
- Male
- Middle Aged