Article
Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males.
Journal of internal medicine - 1 Jul 1998
Hautanena A, Lankinen L, Kupari M, Jänne O A, Adlercreutz H, Nikkilä H, White P C
Abstract excerpt
OBJECTIVES: Two diallelic polymorphisms, one in the transcriptional regulatory region (promoter) and the other in the second intron, have been identified in the aldosterone synthase (CYP11B2) gene encoding aldosterone synthase, the enzyme catalysing the last steps of aldosterone biosynthesis. We have examined the associations between these genetic variations and adrenocortical function in a cohort of Finnish...
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