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Article

An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects.

Clinical endocrinology - 1 Jun 2001

Davies E, Holloway C D, Ingram M C, Friel E C, Inglis G C, Swan L, Hillis W S, Fraser R, Connell J M

Abstract excerpt

OBJECTIVE: Previous evidence suggests that the efficiency of 11beta-hydroxylase is at least partly heritable and also that it may be mildly impaired in essential hypertension. In both cases, assessment of activity was based on the response of 11-deoxycorticosterone (DOC) and 11-deoxycortisol to ACTH. The gene (CYP11B1) coding for this enzyme is highly homologous with and lies a relatively short distance...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Corticosterone

Share to Cytochrome P-450 CYP11B2

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Share to Polymorphism, Genetic

Share to Steroid 11-beta-Hydroxylase

Source

Identifiers

PMID: 11422117
DOI: 10.1046/j.1365-2265.2001.01264.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects.PMID 11422117Read ↗

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Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.Semantic proximity Read ↗

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