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Article

The vaccinia virus A18R DNA helicase is a postreplicative negative transcription elongation factor.

Journal of virology - 1 Sept 1998

Xiang Y, Simpson D A, Spiegel J, Zhou A, Silverman R H, Condit R C

Abstract excerpt

Loss of vaccinia virus A18R gene function results in an aberrant transcription profile termed promiscuous transcription, defined as transcription within regions of the genome which are normally transcriptionally silent late during infection. Promiscuous transcription results in an increase in the intracellular concentration of double-stranded RNA, which in turn results in activation of the cellular 2-5A pathway...

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Identifiers

PMID: 9696793
DOI: 10.1128/JVI.72.9.7012-7023.1998
PMCID: PMC109921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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