Article
Temperature-sensitive mutants in the vaccinia virus A18R gene increase double-stranded RNA synthesis as a result of aberrant viral transcription.
Virology - 1 May 1993
Bayliss C D, Condit R C
Abstract excerpt
Mutations in the vaccinia gene A18R cause activation of the cellular ribonucleolytic 2-5A pathway. To determine the mechanism of 2-5A pathway activation, mutant infections were analyzed for synthesis of double-stranded RNA and for transcription of individual virus genes. At late times postinfecti...
Topics
- 2',5'-Oligoadenylate Synthetase
- Dactinomycin
- Endoribonucleases
- Enzyme Activation
- Gene Expression Regulation, Viral
- Genes, Viral
- Isatin
- Mutation
- RNA, Double-Stranded
- RNA, Ribosomal
- RNA, Viral
- Transcription, Genetic
- Vaccinia virus