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Article

The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro.

Journal of virology - 1 Dec 1995

Liu K, Lemon B, Traktman P

Abstract excerpt

The genetic complexity of vaccinia virus is such that as well as encoding its own transcription and replication machinery, it encodes two protein kinases and a protein phosphatase. The latter enzyme, designated VH1, is a prototype for the dual-specificity class of phosphatases. Here we report that the H1 phosphatase is encapsidated within vaccinia virions and describe the construction of a viral recombinant in...

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Identifiers

PMID: 7494294
DOI: 10.1128/JVI.69.12.7823-7834.1995
PMCID: PMC189726

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