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Article

RNA-Seq Based Transcriptome Analysis of the Type I Interferon Host Response upon Vaccinia Virus Infection of Mouse Cells.

Journal of immunology research - 1 Jan 2017

Hernáez Bruno, Alonso Graciela, Alonso-Lobo Juan Manuel, Rastrojo Alberto, Fischer Cornelius, Sauer Sascha, Aguado Begoña, Alcamí Antonio

Abstract excerpt

Vaccinia virus (VACV) encodes the soluble type I interferon (IFN) binding protein B18 that is secreted from infected cells and also attaches to the cell surface, as an immunomodulatory strategy to inhibit the host IFN response. By using next generation sequencing technologies, we performed a detailed RNA-seq study to dissect at the transcriptional level the modulation of the IFN based host response by VACV and...

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Identifiers

PMID: 28280747
DOI: 10.1155/2017/5157626
PMCID: PMC5322442

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