Article
Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses.
Blood - 15 Aug 1998
Cockayne D A, Muchamuel T, Grimaldi J C, Muller-Steffner H, Randall T D, Lund F E, Murray R, Schuber F, Howard M C
Abstract excerpt
CD38 is a membrane-associated ecto-nicotinamide adenine dinucleotide (NAD+) glycohydrolase that is expressed on multiple hematopoietic cells. The extracellular domain of CD38 can mediate the catalysis of NAD+ to cyclic adenosine diphosphoribose (cADPR), a Ca2+-mobilizing second messenger, adenosi...
Topics
- ADP-ribosyl Cyclase
- ADP-ribosyl Cyclase 1
- Alleles
- Animals
- Antibody Formation
- Antigens
- Antigens, CD
- Antigens, Differentiation
- Antigens, T-Independent
- Bone Marrow Transplantation
- Female
- Hematopoiesis
- Immunization
- Lymphocyte Cooperation
- Male
- Membrane Glycoproteins
- Mice
- Mice, Inbred C57BL