Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of CD38 enhances CD19 chimeric antigen receptor T cell function

24 May 2024

Abstract excerpt

. CD38 is a multifunctional ectoenzyme with hydrolase and cyclase activities. Reintroduction of CD38 mutants into T cells lacking CD38 provided further evidence supporting the understanding that CD38 plays a crucial role in producing the immunosuppressive metabolite adenosine and utilizing nicotinamide adenine dinucleotide (NAD) in human T cells. Taken together, these results highlight a role for CD38 as an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38912091
DOI: 10.1016/j.omton.2024.200819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of CD38 enhances CD19 chimeric antigen receptor T cell functionPMID 38912091Read ↗

Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses.Semantic proximity Read ↗

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of AgingSemantic proximity Read ↗

The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting.Semantic proximity Read ↗

CD38-CAR human NK cells in combination with ATRA enhance cytotoxicity against CD38-expressing hematologic malignanciesSemantic proximity Read ↗

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generationSemantic proximity Read ↗

Regulation of intracellular levels of NAD: a novel role for CD38.Semantic proximity Read ↗

Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cellsSemantic proximity Read ↗

Monitoring and characterizing soluble and membrane-bound ectonucleotidases CD73 and CD39Semantic proximity Read ↗

CD38 as a Therapeutic TargetSemantic proximity Read ↗

A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferationSemantic proximity Read ↗

Deletion of CD38 mitigates the severity of NEC in experimental settings by modulating macrophage-mediated inflammationSemantic proximity Read ↗

Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor ImmunitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.