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Article

Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation.

Aging - 1 Aug 2011

Sahar Saurabh, Nin Veronica, Barbosa Maria Thereza, Chini Eduardo Nunes, Sassone-Corsi Paolo

Abstract excerpt

The Intracellular levels of nicotinamide adenine dinucleotide (NAD(+)) are rhythmic and controlled by the circadian clock. However, whether NAD(+) oscillation in turn contributes to circadian physiology is not fully understood. To address this question we analyzed mice mutated for the NAD(+) hydrolase CD38. We found that rhythmicity of NAD(+) was altered in the CD38-deficient mice. The high, chronic levels of...

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PMID: 21937766
DOI: 10.18632/aging.100368
PMCID: PMC3184980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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