Article
CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype.
EMBO molecular medicine - 9 May 2022
de Zélicourt Antoine, Fayssoil Abdallah, Dakouane-Giudicelli Mbarka, De Jesus Isley, Karoui Ahmed, Zarrouki Faouzi, Lefebvre Florence, Mansart Arnaud, Launay Jean-Marie, Piquereau Jerome, Tarragó Mariana G, Bonay Marcel, Forand Anne, Moog Sophie, Piétri-Rouxel France, Brisebard Elise, Chini Claudia C S, Kashyap Sonu, Fogarty Matthew J, Sieck Gary C, Mericskay Mathias, Chini Eduardo N, Gomez Ana Maria, Cancela José-Manuel, de la Porte Sabine
Abstract excerpt
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration. Two important deleterious features are a Ca2+ dysregulation linked to Ca2+ influxes associated with ryanodine receptor hyperactivation, and a muscular nicotinamide adenine dinucleotide (NAD+ ) deficit. Here, we identified that deletion in mdx mice of CD38, a NAD+ glycohydrolase-producing modulators of Ca2+ signaling, led to a...
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