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Article

Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.

Nature communications - 13 Jun 2016

Spanier Justin A, Frederick Daniel R, Taylor Justin J, Heffernan James R, Kotov Dmitri I, Martinov Tijana, Osum Kevin C, Ruggiero Jenna L, Rust Blake J, Landry Samuel J, Jenkins Marc K, McLachlan James B, Fife Brian T

Abstract excerpt

Monoclonal antibodies specific for foreign antigens, auto-antigens, allogeneic antigens and tumour neo-antigens in the context of major histocompatibility complex II (MHCII) are highly desirable as novel immunotherapeutics. However, there is no standard protocol for the efficient generation of monoclonal antibodies that recognize peptide in the context of MHCII, and only a limited number of such reagents exist....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27292946
DOI: 10.1038/ncomms11804
PMCID: PMC4909947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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