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Article

Longitudinal analysis of circulating myeloma cells detected by allele specific mRNA in situ hybridization.

American journal of hematology - 1 Aug 1998

Brown R D, Luo X F, Gibson J, Brisco M, Sykes P, Morley A, Joshua D

Abstract excerpt

Individual myeloma cells in the peripheral blood of 7 patients with multiple myeloma were detected by mRNA in situ hybridization (ISH) using biotinylated antisense oligonucleotide probes to non-germline sequences of the CDR3 region of the immunoglobulin heavy chain gene. Peripheral blood samples from these patients were studied over a period of 2-3 years. The number of circulating myeloma cells varied from...

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PMID: 9692389
DOI: 10.1002/(sici)1096-8652(199808)58:4<273::aid-ajh4>3.0.co;2-n

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