Article
Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma.
Haematologica - 1 Oct 2010
Rasmussen Thomas, Haaber Jacob, Dahl Inger Marie, Knudsen Lene M, Kerndrup Gitte B, Lodahl Marianne, Johnsen Hans E, Kuehl Michael
Abstract excerpt
BACKGROUND: Several laboratories have shown that cells with a memory B-cell phenotype can have the same clonotype as multiple myeloma tumor cells. DESIGN AND METHODS: The aim of this study was to determine whether some memory B cells have the same genetic alterations as their corresponding multiple myeloma malignant plasma cells. The methodology included sorting multiple myeloma or memory B cells into RNA...
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