Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype.

doi:10.1016/s0165-5728(98)00096-4

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Article

Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype.

Journal of neuroimmunology - 1 Aug 1998

Licastro F, Mallory M, Hansen L A, Masliah E

Abstract excerpt

Levels of alpha-1-antichymotrypsin (ACT) were higher in brain homogenates of patients with Alzheimer's disease (AD) than controls. Brain tissues from the same patients and controls were immunostained with antibodies specific for microglia or astrocytes, the leukocyte common antigen (CD45) and gli...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Astrocytes
Brain
Cell Aggregation
Coloring Agents
Female
Genotype
Glial Fibrillary Acidic Protein
Humans
Immunohistochemistry
Leukocyte Common Antigens
Male
Phenotype
Regression Analysis

Source

Open in PubMed

Identifiers

PMID: 9688331
DOI: 10.1016/s0165-5728(98)00096-4

Genes

APOE
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9688331-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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