Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer's disease.

Scientific reports - 23 Oct 2017

Koch Giacomo, Di Lorenzo Francesco, Loizzo Stefano, Motta Caterina, Travaglione Sara, Baiula Monica, Rimondini Roberto, Ponzo Viviana, Bonnì Sonia, Toniolo Sofia, Sallustio Fabrizio, Bozzali Marco, Caltagirone Carlo, Campana Gabriele, Martorana Alessandro

Abstract excerpt

In Alzheimer's disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, the interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanism invokes the dysfunction of synaptic plasticity. We investigated how CSF tau interacts with APOE genotype in AD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apoptosis

Share to Astrocytes

Share to Cell Survival

Share to Cognitive Dysfunction

Share to Neuronal Plasticity

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29062035
DOI: 10.1038/s41598-017-14204-3
PMCID: PMC5653826

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer's disease.PMID 29062035Read ↗

ApoE-Dependent Plasticity in Alzheimer's DiseaseSemantic proximity Read ↗

Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample.Semantic proximity Read ↗

Association of plasma glial fibrillary acidic protein and APOE-ε4 with Alzheimer's disease.Semantic proximity Read ↗

Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologiesSemantic proximity Read ↗

Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived ModelsSemantic proximity Read ↗

ApoE4-carrying Human Astrocytes Oversupply Cholesterol into Neurons and Promote Aβ GenerationSemantic proximity Read ↗

APOE genotype and astrocyte activity collectively influence AD biomarkers and Aβ burden.Semantic proximity Read ↗

ApoE4 expression disrupts tau uptake, trafficking, and clearance in astrocytesSemantic proximity Read ↗

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease.Semantic proximity Read ↗

Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele epsilon 4 during 14 months follow-up.Semantic proximity Read ↗

Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer’s diseaseSemantic proximity Read ↗

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.