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Article

Post-stroke dementia is associated with alpha(1)-antichymotrypsin polymorphism.

Journal of the neurological sciences - 15 Jul 2005

Klimkowicz Aleksandra, Słowik Agnieszka, Dziedzic Tomasz, Polczyk Romuald, Szczudlik Andrzej

Abstract excerpt

BACKGROUND AND PURPOSE: Alpha-1-antichymotrypsin (ACT) is an acute phase protein involved in inflammatory reaction, promoting the assembly of beta amyloid protein into filaments and contributing to its resistance to proteolytic digestion. The aim of our study was to determine ACT signal peptide polymorphism (A/T) as a possible risk factor for post-stroke dementia (PSD). METHODS: 142 consecutive ischemic stroke...

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Identifiers

PMID: 15935385
DOI: 10.1016/j.jns.2005.02.012

Genes

PSD

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