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Article

A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease.

Neurobiology of aging - 1 Apr 2005

Licastro Federico, Chiappelli Martina, Grimaldi Luigi M E, Morgan Kevin, Kalsheker Noor, Calabrese Elena, Ritchie Alistair, Porcellini Elisa, Salani Giuliana, Franceschi Massimo, Canal Nicola

Abstract excerpt

Increased levels of alpha-1-antichymotrypsin (ACT), a protease inhibitor and an acute phase protein, have been found in the brain and peripheral blood of patients with Alzheimer's disease (AD). Patients from northern Italy with a clinical diagnosis of probable AD, and patients with early onset AD (EOAD) from UK with AD neuropathological diagnosis were genotyped for a new polymorphism in the promoter region of the...

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Identifiers

PMID: 15653173
DOI: 10.1016/j.neurobiolaging.2004.05.001

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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