Article
Mutant p53 and the response to chemotherapy and radiation.
Sub-cellular biochemistry - 1 Jan 2014
Tchelebi Leila, Ashamalla Hani, Graves Paul R
Abstract excerpt
In addition to playing roles in the genesis and progression of cancer, mutant p53 also appears to play a significant role in the response to cancer therapy. In response to chemotherapy and radiation, two mainstays of cancer treatment, most cancer cells harboring p53 mutations show a reduced sensitivity compared to cells lacking p53 or those with wild type p53. However, there are also many instances where mutant...
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