Mutational and LOH analyses of p53 alleles in colon tumors induced by 1,2-dimethylhydrazine in F1 hybrid mice.

doi:10.1093/carcin/16.11.2659

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Article

Mutational and LOH analyses of p53 alleles in colon tumors induced by 1,2-dimethylhydrazine in F1 hybrid mice.

Carcinogenesis - 1 Nov 1995

Okamoto M, Ohtsu H, Kominami R, Yonekawa H

Abstract excerpt

To elucidate the role of p53 in colon tumorigenesis in mice, we examined allele loss and mutational alteration of the p53 gene in colon tumors induced by 1,2-dimethylhydrazine (DMH) in F1 hybrid mice. Intragenic polymorphism of the p53 gene among parental strains enabled us to assess allele loss...

Topics

1,2-Dimethylhydrazine
Alleles
Amino Acid Sequence
Animals
Base Sequence
Chromosome Deletion
Colonic Neoplasms
Dimethylhydrazines
Genes, p53
Humans
Hybridization, Genetic
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mutation

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